Citicoline is a natural substance that is found throughout the human body. It is the metabolic forerunner of phosphatidylcholine, a group of natural lipids, which are a major part of cell membranes. Your body uses choline, a nutrient in wheat germ, liver, eggs and cruciferous vegetables, to create citicoline. It then uses the substance to make phosphatidylcholine and acetylcholine, a biochemical messenger that enhances the storage and recollection of information. Citicoline is also one of the high quality ingredients in Doxiderol, a holistic supplement.

Since scientists discovered citicoline in 1955, research has confirmed that the nutrient has several important roles in brain health and cognitive function. It enhances retention of information, recall and overall memory. Citicoline helps the brain replenish grey matter. This part of the brain consists of nerve cells and receptors that process information as well as other structures that support and protect the brain.

According to studies, grey matter begins to shrink when a person is in their mid-twenties. In addition to the aging process, your brain shrinks due to stress, disease, sleep deprivation and nutritional deficiencies. If your choline levels are low or your body needs  acetylcholine, it will take choline from your cell membranes to meet its metabolic requirements. Approximately 30 percent of your grey matter is phosphatidylcholine. Citicoline promotes brain health by giving your body the raw materials that it needs to repair and generate brain tissue and to make acetylcholine.

Citicoline also increases the production of other biochemical messengers, such as norepinephrine and dopamine. Norepinephrine and dopamine enhance cognitive performance by alleviating depression and anxiety. Dopamine enables you to perform tasks that require analysis, focus and memory. It can also reduce symptoms associated with Attention Deficit Disorder. Studies indicate that citicoline eliminates the risk of memory impairment due to environmental factors because it prevents the accumulation of toxic substances in the brain. Citicoline increases energy production inside healthy and damaged cells.

A study published in the May 1996 issue of the Archives of Neurology evaluated the effect of citicoline on the verbal memory of volunteers who were 50 to 85 years old. Some of the participants had cognitive impairment. The researchers used a double-blind, placebo-controlled, crossover study configuration. A double-blind study protects the integrity of the results by shielding the identity of the substances. Neither the participants nor the researchers knew who received citicoline or the placebo, an inactive ingredient. The scientists assigned the participants to receive one ingredient and then gave them the opposite ingredient during the crossover phase. The results demonstrated that citicoline enhanced verbal memory in older adults who had impaired memories. The scientists concluded that citicoline is beneficial in the treatment of age-related cognitive impairment

In 2012, a University of Utah School of Medicine study analyzed the cognitive effects of citicoline on 60 female volunteers. Unlike other citicoline studies that included participants with cognitive impairments due to injury or illness, this study focused on healthy women. During the 28-day study, the women were assigned to receive citicoline or a placebo. The citicoline group demonstrated better recall, focus and attention on tests than the placebo group. According to the researchers, citicoline supplements can improve cognitive impairments due to stress and normal aging.

A national survey revealed that less than 10 percent of Americans consume enough choline-rich foods to meet their metabolic requirements. A choline deficiency deprives your body of the material that it needs to maintain healthy brain tissue and to perform cognitive tasks. Doxiderol is a proprietary nutritional supplement that contains citicoline and other brain health ingredients. The supplement increases acetylcholine levels and enhances memory, concentration and focus.