All Natural Ingredients

  • Increase Focus
  • Enhance Memory
  • Boost Energy


Caffeine is one of the most widely studied and consumed food staples in the world. It is a natural ingredient in cocoa beans, coffee beans and tea leaves. For thousands of years, people have used caffeine for its energizing effects and ability to ease mental and physical fatigue. Since caffeine’s discovery in 1819, scientists have conducted more than 19,000 studies to determine its impact on human health. The research has yielded substantial evidence that caffeine has numerous cognitive benefits.

Caffeine promotes cognitive performance by preserving acetylcholine, a biochemical messenger that transmits information between nerve cells. Caffeine prevents an enzyme from breaking acetylcholine down into smaller components. This process enables acetylcholine to work longer and at higher levels in the brain. The benefit is enhanced cognitive function and memory. Although caffeine has numerous health benefits, it can cause negative side effects, such as insomnia and restlessness.

Caffeine’s molecular structure resembles adenosine, a biochemical messenger. The substances have opposite effects in the body. If the two chemicals were driving a car, caffeine would step on the gas pedal, and adenosine would apply the brakes. In the nervous system, adenosine occupies receptors on nerve cells, which enable it to promote sedation and decrease the activity of other biochemical messengers, such as dopamine and glutamate. Dopamine has a role in memory and attention, and glutamate helps the brain encode memories. Glutamate also enhances memory and learning by increasing the speed of message transmission between cells.

Caffeine’s structural resemblance to adenosine enables it to occupy adenosine’s receptors and block its activity. The result is enhanced mental alertness and a reduction of physical fatigue. Caffeine also increases the activity of epinephrine, norepinephrine and serotonin, biochemical messengers that increase mental focus and a sense of wellbeing. In addition to these effects, caffeine has other cognitive benefits.

According to the 1981 issue of Orthomolecular Psychiatry, caffeine intake increases the clarity, speed and association of thoughts. In 2002, researchers published a review of the medical literature on caffeine. According to the Journal of Chemical Toxicology study, caffeine decreases fatigue and increases mental alertness. It also enhances the brain’s ability to encode new information through its effect on acetylcholine. The authors concluded that caffeine improves concentration and focus.

In October 2003, researchers evaluated the effect of caffeine on cognition and fatigue. The Brain and Cognition study confirmed that caffeine decreases fatigue and improves attention. The authors noted that caffeine’s benefits are due to its effects on adenosine and dopamine.

A double-blind study published in the July 2005 issue of Psychopharmacology reported the effects of caffeine on cognitive task and fatigue. Twenty-four healthy volunteers were assigned to receive caffeine or a placebo, an inactive ingredient. The caffeine group accomplished cognitive and motor tasks faster than the placebo group. The researchers concluded that caffeine enhances cognitive performance by reducing fatigue.

In the July 2012 issue of the Journal of Alzheimer’s Disease, scientists analyzed the effect of caffeine on cognitive impairment. The four-year study monitored the thought process and memory of 124 participants who were 65 to 88 years old. The participants who consumed caffeine had a lower risk of developing Alzheimer’s disease. The study also demonstrated that caffeine significantly delays or prevents the progression of the disease in older people who have existing mild cognitive impairment. According to the scientists, caffeine readily crosses into the brain and prevents the body from producing beta-amyloid, a protein associated with Alzheimer’s disease.

Doxiderol is a holistic supplement that contains caffeine and other natural ingredients, which support cognitive performance. The unique proprietary blend enables you to enjoy the benefits of caffeine without experiencing undesirable stimulatory effects.